Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo

Summary The rodent external globus pallidus (GPe) contains two main neuronal subpopulations, prototypic and arkypallidal cells, which differ in their cellular properties. Their functional synaptic connectivity is largely unknown. Here we studied the membrane properties, inputs, sensory responses of these subpopulations mouse GPe. We performed in vivo whole-cell recordings GPe neurons used optogenetic stimulation to dissect afferent inputs from striatum subthalamic nucleus (STN). Both received barrages excitatory inhibitory during slow wave activity responded with distinct multiphasic patterns. Prototypic cells synaptically inhibited cells. input STN striatal medium spiny (MSNs). Although indirect pathway MSNs strongly targeted direct selectively show that subtypes have patterns underlie respective roles.